There is an increasing interest in the use of marijuana products to treat grave neurological disorders like Parkinson’s disease and Multiple Sclerosis. However the American Academy of Neurology (AAN) has said in a position statement that anecdotal evidence is not enough to support this use because:

  1. Its efficacy is not supported by properly conducted clinical trials
  2. Its clinical safety is still being questioned for long-term use
  3. Its interaction with prescription medications is still unknown

The AAN has requested the reclassification of marijuana-based products from their current Schedule 1 status according the DEA guidelines in order to allow its use under International Review Board (IRB) clinical protocols. This administrative step is especially needed to protect the investigators who study patients with grave diseases and/or children with vulnerable brains. Most of the standardized preparations used in clinical trials are not available in the USA and the results cannot be extrapolated to non-standardized weed. Moreover most marijuana products sold in the USA are not controlled by any federal agency, for which they may not contain the labelled ingredients.

Epidiolex is a purified, 99% oil-based Cannabidiol (CBD) product that delivers known and consistent amounts of drug in each dosage; the FDA has given selected Epilepsy centers the permission for its “compassionate use” in some the 30% of patients who do respond to the traditional therapies. An open-label study—without a placebo control—of this drug that included 214 patients aged 2 to 26 years old with epilepsy refractory to currently available treatments showed that seizures decreased an average of 54% in the 12 weeks. Patients taking Onfi had a better response than those who did not. Two studies of the use of Epidiolex in the Lennox-Gastaut syndrome and the Dravet syndrome have recently been completed with encouraging results.

The most common side effects observed in the 214 people were: sleepiness (21%), diarrhea (17%), fatigue (17%) and decreased appetite (16%). The safety data from the trials with epileptic children had similar side effects.

What do you think? Please tell us.

Don’t leave me alone.

 

 

 

 

 

17 thoughts on “Cannabis in Epilepsy

  1. Sorry for the typo. It should read “thank you.” You can tell I am already having my daily dosage of that miracle medicine called ” du vin rouge.” Salut!

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  2. First of all the science is there but nobody wants to look for it. Ugh! We both know that CBD helps MOST conditions and the side effects are much less than those of prescription drugs. These days you almost need a drug to help with the side effects of the drug you are taking for the condition. It is a viscous cycle. Natural products tend to mimic the body’s own receptor sites whereby no free radicals are released into the system causing disease. I read something interesting a few days ago that I will share with you. I’d like to do more research on the subject. It was that most illnesses are caused by Cannabinoid Deficiencies. Isn’t that interesting. That statement gives further credibility to a quote from one of my blog posts: “It [cannabis] has captured these molecules that help our bodies regulatory system be more effective. The bottom line is it’s a dietary essential that helps all 210 cell types function more effectively. I don’t even refer to it as medicine anymore, strictly as a dietary essential.” ~ Dr. William L. Courtney
    This is the way of the future. Great article by the way!

    Liked by 1 person

    1. Goid evening and hanks for reading and commenting my article dear Roxy. Indeed it should be considered as a quasi-dietary supplement but even those need some kind of techical analysis and certification by the reasonable regulatory agencies. I am not talking of course about the fascist ban on Cannabis that has been in effect in this country ever since the Volsted Act. No, I am taking about a proficient, fair analysis of the composition of each presentation to make sure that the consumers, who will usually be very sick and vulnerable patients, do not get cheated by unscrupulous vendors. Don’t you agree dear? By the way the prohibition on Alcohol was lifted in the 30s but the one on marihuana lingered on until our days. It’s been way, way too long.
      A big kiss. Arrivederci!

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      1. Agreed. I had a phone conversation today with the largest online retailer of CBD products about quality and third party testing. Bottom line is they certify all the products they represent, have testing certifications and 3rd party verifications, ALL AVAILABLE to customers. DO not buy CBD products from China. LOL One must be careful where they purchase products. I research CBD companies before I recommend them on my blog or to bloggers who email me about what products to take. The company indicated to me that they were making big changes to their site to spotlight ORGANIC companies. There are huge differences in quality according to the gentleman I spoke with. It is good for people to do their homework as HEMP can be used to clean up industrial waste, etc. You certainly do not want products made with this hemp.
        Everyday we are making a little more progress to be rid of this disingenuous prohibition. It is also important to support grass roots movements. Hugs for now!

        Liked by 1 person

      2. Well, I’m.glad we’re making progress in cleaning the field because eventually my patients and your customers will benefit. Please send me some reading material and/or useful links about those important issues to: email@drmolaplume.com
        Do you know if Cannabis might cure my sonnambulism? Please read my next Saturday’s blog titled: ” The sleepwalker.” I need help, girl. Another kiss. Ciao!

        Liked by 1 person

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